|
KMID : 0613820130230040495
|
|
Journal of Life Science
2013 Volume.23 No. 4 p.495 ~ p.500
|
|
|
Anti-inflammatory Effect of HaGF peptide of Harmonia axyridis
|
|
Kim Dong-Hee
Kim Hyeon-Jeong
Lee Jin-Young
Hwang Jae-Sam
Kim In-Woo
Lee Seul-Gi
Jeong Hyeon-Guk
An Bong-Jeun
|
|
|
Abstract
|
|
|
|
Harmonia axyridis is known to display diverse biological activities, such as growth promotion. However, few studies have investigated the effect of H. axyridis on inflammation of the skin. In this study, we explored the anti-inflammatory effect of the Harmoniasin gene fragment (HaGF) peptide from H. axyridis on macrophage cells. During the entire experimental period, 5, 25, 50, and 100 μg/ml of HaGF showed no cytotoxicity. However, at these concentrations, HaGF inhibited the activity of iNOS and COX-2 by 51% and 49%, respectively. In addition, the HaGF extract reduced the release of inflammatory cytokines, including TNF-a and IL-6. Therefore, HaGF has been LPS-induced macrophage Raw 264.7 cells could be expected from the inhibitory effects of the inflammatory.
|
|
|
KEYWORD
|
|
|
Anti-inflammatory, COX-2, Harmonia axyridis, iNOS, lipopolysaccharide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|